‘Indeed, that may be about appropriate. I search for a Bodily idea of biological techniques inside of a bottom-up way. I feel you could distinguish three traces of investigate in my group at this time. The very first worries chromosome composition: how do you have a metre-extensive DNA polymer folded and organised in such a microscopic cell? We've got formulated visualisation techniques that enable us to review how, such as, SMC proteins loop DNA (video on Youtube) to be able to Create up chromosomes.
Human Rad51 filaments on double- and single-stranded DNA: correlating typical and irregular sorts with recombination perform.
Dynamics of initiation, termination and reinitiation of DNA translocation via the motor protein EcoR124I
Considering that 2000, Dekker has shifted the main target of his get the job done towards biophysics the place he experiments the properties of solitary biomolecules and cells utilizing the tools of nanotechnology. This transformation of subject was pushed by his fascination with the outstanding operating of Organic molecular buildings, as well as from the extended-expression standpoint that numerous cees dekker fascinating discoveries could be predicted With this industry.[five] Present-day lines of analysis in his biophysics group are inside the regions of:[6]
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The coiled-coil of your human Rad50 DNA mend protein consists of unique segments of enhanced flexibility
Length Charge of unique carbon nanotubes by nanostructuring While using the scanning tunneling microscope
Example (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim in the pore is highlighted in pink, and also a 3D rendering from the movement from the DNA rod is shown.
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Bulk-surface coupling identifies the mechanistic link amongst Min-protein patterns in vivo As well as in vitro
[fourteen] In 2005 Dekker turned associated with Netherlands-wide discussions about Clever Design and style, a motion that he has because Plainly distanced himself from. Dekker advocates that science and faith usually are not in opposition but can be harmonized.
2001, discovery of solitary-electron transistors at area temperature based upon nanotubes; realization of initially logic circuits with carbon nanotube equipment; and discovery of your molecular structure of DNA repair enzymes with AFM
Visualization of unstained DNA nanostructures with Sophisticated in-target transmission electron microscopy approaches
Supercoiling-dependent DNA binding: quantitative modeling and apps to bulk and single-molecule experiments